[PDF] Cell Cycle Regulation by Heat Shock Transcription Factors | Semantic Scholar (2024)

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7 Citations

Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases
    Yasuko TokunagaK. OtsuyamaS. KakutaNaoki Hayashida

    Medicine, Biology

    International journal of molecular sciences

  • 2022

The fact HSF2 has a relationship with various factors is not yet widely recognized; therefore, the biological significance of HSF1 has been underestimated and widely communicated to researchers and readers in broad research fields is hoped.

Small heat shock proteins as modulators of cell death in Plasmodium falciparum parasites and its human host
    Francisca Magum TimothyT. Zininga

    Medicine, Biology

    Frontiers in Cell Death

  • 2023

The conserved and distinctive motifs of sHsps from the human host and the parasite are discussed, offering insights into shared and unique attributes and illuminating the potential for species-specific targeting of s Hsps, as players in cell death processes that may foster innovative biomarker identification approaches.

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Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass
    P. Attfield


    Critical reviews in biotechnology

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Both the cell replication and conditioning phases need to be optimized and considered in concert to ensure good biomass production economics, and optimum performance of industrial yeasts in food and fermentation applications.

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Multiple molecular and cellular mechanisms of the antitumour effect of dihydromyricetin (Review)
    Tian-Yu XiaRunzhi Zhu

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    Biomedical reports

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The present review is expected by the authors to draw attention to the potential of DHM as an antitumour drug and provide valuable references for the clinical translation of DHM research and the development of related treatment strategies.

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Hypoxia-elicited Exosomes Promote the Chemoresistance of Pancreatic Cancer Cells by Transferring LncROR via Hippo Signaling
    Huizhi WangJ. Min Min Xu

    Medicine, Biology

    Journal of Cancer

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The hypoxia-induced tumor-derived exosomes (Hexo) could promote stemness and induce resistance to gemcitabine in pancreatic cancer cells, and exosomal lncROR may serve as a candidate target of chemotherapy for pancreatic cancers.

Editorial to Summarize the Papers Published in the Special Issue “10th Anniversary of Cells—Advances in Cell Cycle”
    Zhixiang Wang



  • 2022

To celebrate its 10th anniversary, the prestigious journal Cells launched a series of Special Issues in 2021, with a focus on regenerative medicine and drug discovery.

Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms.
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142 References

Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.
    Kevin A. MoranoD. J. Thiele

    Biology, Medicine

    Gene expression

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Recent advances toward understanding how cells transmit growth control and developmental signals, and interdigitate cellular physiology, to regulate HSF function are reviewed.

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How Proteolysis Drives the Cell Cycle
    R. KingR. DeshaiesJ. PetersM. Kirschner


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Proteolysis drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics, and also how proteolysis may directly trigger the transition from metaphase to anaphase.

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Regulation of Protein Phosphatase 2A Activity by Heat Shock Transcription Factor 2*
    Yiling HongK. Sarge


    The Journal of Biological Chemistry

  • 1999

HSF2 is identified as a dual function protein, capable of regulating both hsp expression and PP2A activity, and could function as a mechanism by whichhsp expression is integrated with the control of cell division or other PP2 A-regulated pathways.

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A trans-Activation Domain in Yeast Heat Shock Transcription Factor Is Essential for Cell Cycle Progression during Stress
    K. MoranoN. SantoroK. KochD. Thiele


    Molecular and Cellular Biology

  • 1999

It is demonstrated that HSF(1-583) cells undergo reversible cell cycle arrest at 37°C in the G2/M phase of the cell cycle and exhibit marked reduction in levels of the molecular chaperone Hsp90.

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Cdc20: a WD40 activator for a cell cycle degradation machine.
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    Molecular cell

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Regulation of CDK/cyclin complexes during the cell cycle.
    Manuel ArellanoSergio Moreno


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Activation of heat shock transcription factor 1 to a DNA binding form during the G1 phase of the cell cycle
    Jacqueline L. BruceChangmin Chen Stuart K. Calderwood


  • 1999

Enter into G1 did not lead to HSF1 hyperphosphorylation or increased activity of a heat shock promoter-reporter gene and did not cause the induction of heat shock protein 70 expression, thus HSF 1, previously implicated in the heat shock response is activated to a DNA binding from in G1 under non-stress conditions and may play a role in G 1 regulation that does not involve the transcription of heatshock genes.

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Functionally hom*ologous cell cycle control genes in budding and fission yeast
    D. BeachB. DurkaczP. Nurse



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It is concluded that the cdc 2 and cdc 28 genes perform hom*ologous cell cycle control functions in the two organisms.

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Activation of heat-shock transcription factor 1 in heated Chinese hamster ovary cells is dependent on the cell cycle and is inhibited by sodium vanadate.
    L. HeM. Fox


    Radiation research

  • 1999

The hypothesis thatcell cycle-dependent binding of HSF1 to HSE is the cause of the cell cycle-specific expression of HSP72 in heated CHO cells and is regulated by phosphorylation is supported.

  • 8
Mechanism of hsp70i Gene Bookmarking
    Hongyan XingD. Wilkerson K. Sarge



  • 2005

Hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase 2A, and interacts with the CAP-G subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of Condensin complexes in the vicinity, thereby preventing compaction at this site.

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    [PDF] Cell Cycle Regulation by Heat Shock Transcription Factors | Semantic Scholar (2024)


    How does heat shock affect transcription? ›

    During attenuation of the heat shock response, the transcriptional activity of HSF1 is repressed by direct binding of HSP70 and Hdj-1, and the trimers are negatively regulated by HSF-binding protein 1 (HSBP1), which binds both to the hydrophobic heptad repeat of HSF1 and to HSP70.

    What transcription factor is involved in cell cycle regulation? ›

    Mammalian cell cycle transcriptional regulation is dependent on E2F and pocket proteins. The E2F family of transcription factors and their dimerization partner proteins act as transcriptional regulators of G1– S transcription.

    What is the transcriptional regulation of heat shock genes? ›

    The regulation of heat shock protein gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF) [82]. An intracellular signalling cascade leads to the activation of HSP gene transcription thus protein synthesis of a specific HSP type.

    What is the function of the HSF gene? ›

    A critical role that HSF molecules play in all eukaryotic cells is to activate both basal and stress-induced transcription of genes encoding components of the Hsp90 chaperone complex, which is essential for the folding, and maintenance in an activation-competent state, of a large number of key cellular regulatory ...

    What happens to cells during heat shock? ›

    The heat shock response involves the clustering of proteins and mRNA into “condensates,” in a process known as condensation. To recover from stress, these condensates must be pulled apart by proteins known as chaperones, the most famous of which is heat shock protein 70 (Hsp70).

    What are three ways transcription factors affect transcription? ›

    How do transcription factors work?
    • Activators. Some transcription factors activate transcription. ...
    • Repressors. Other transcription factors repress transcription. ...
    • Binding sites. The binding sites for transcription factors are often close to a gene's promoter.

    What factors contribute to cell cycle regulation? ›

    These factors include:
    • Hormones.
    • Mitogens.
    • Size of the cell.
    • Growing factors.
    • Physical signals.
    • Chemical signals.
    • Ratio of Karyoplasmic.

    What general transcription factor is most often affected by regulatory transcription factors? ›

    The term TFIID is abbreviated as transcription factor RNA polymerase II. TFIID is a type of complex factor that affects the normal functioning of general transcription factors. It has an important role in the mitotic inhibition of RNA polymerase II transcription. Therefore, the correct answer is (C) TFIID .

    What is the main mechanism of regulation during transcription? ›

    At the level of chromatin state

    The highest level of transcription regulation occurs through the rearrangement of histones in order to expose or sequester genes, because these processes have the ability to render entire regions of a chromosome inaccessible such as what occurs in imprinting.

    What are the heat shock transcription factors gene family? ›

    Heat shock factor (Hsf) is a family of antiretroviral transcription factors that regulate plant defense system against biotic and abiotic stress. To date, few studies have identified and bio-analyzed Hsfs in common bean.

    What are the genes involved in heat shock? ›

    The principal heat-shock proteins that have chaperone activity belong to five conserved classes: HSP33, HSP60, HSP70/HSP110, HSP90, HSP100, and the small heat-shock proteins (sHSPs). A standard nomenclature for human HSP genes is available. Human HSPA genes.

    What mechanism regulates the expression of heat shock genes? ›

    The expression of heat shock proteins including molecular chaperones is regulated by the heat shock transcription factor HSF1. Molecular chaperones function to prevent and repair protein damage through interactions with the misfolded proteins.

    Is HSF a transcription factor? ›

    Heat shock transcription factors (HSFs) are a family of DNA-binding proteins, largely conserved from fungi to humans, that regulate gene expression at the level of transcription1,2.

    What is the function of the heat shock factor 1? ›

    Function. The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells.

    What is the function of MYB transcription factor? ›

    v-Myb myeloblastosis viral oncogene hom*olog (MYB) transcription factors (TFs) represent one of the largest families of a transcription factor in plants. These MYB TFs have important functions in the regulation of the biosynthesis of secondary metabolites in plants.

    How does heat affect transcription? ›

    Temperature appears to alter gene expression at both transcriptional and post-transcriptional steps via DNA and RNA thermosensors. At the transcriptional level, temperature is read out in part via regulation of access of transcriptional machinery to DNA.

    How does heat shock affect DNA? ›

    By exposing cells to a sudden increase in temperature, or heat shock, a pressure difference between the outside and the inside of the cell is created, that induces the formation of pores, through which supercoiled plasmid DNA can enter.

    What are the heat shock transcription factors in plants? ›

    Heat shock transcription factors (HSFs) are the central regulators of HSP expression and are the master regulators of HSR [2, 6, 17]. Under normal conditions, HSFs exist in a monomeric state, and their activities are repressed by inhibitory association with HSPs, such as HSP.

    What are the heat stress transcription factors? ›

    Abstract. Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF).


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